Lian‐Wang Guo, Abdol R Hajipour, Kerim Karaoglu, Timur A Mavlyutov, Arnold E Ruoho

2012/10/15

ChemBioChem

13

15

2277-2289

WILEY‐VCH Verlag

Abstract Sigma (σ) receptors are unique non-opioid binding sites that are associated with a 
broad range of disease states. Sigma-2 receptors provide a promising target for diagnostic 
imaging and pharmacological interventions to curb tumor progression. Most recently, the 
progesterone receptor (PGRMC1, 25 kDa) has been shown to have σ2 receptor-like binding 
properties, thus highlighting the need to understand the biological function of an 18 kDa 
protein that exhibits σ2-like photoaffinity labeling (denoted here as σ2-18k) but the amino ...