Abdol R Hajipour, Seyed Hadi Nazemzadeh, Fatemeh Mohammadsaleh

2014/1/15

Tetrahedron Letters

55

3

654-656

Pergamon

Abstract Choline chloride–CuCl (ChCl–CuCl) has been employed as an efficient catalytic 
system in the palladium-free Sonogashira-type cross-coupling reactions of phenylacetylene 
with a variety of aryl halides. Choline chloride, as an effective ligand and a quaternary 
ammonium salt, demonstrated an efficient stabilizing effect on the Cu (I) species during the 
reaction. This homogeneous catalytic system is attractive in view of its ease of application 
and low cost.