Uyen B Chu, Sevahn Kayaneh Vorperian, Kenneth A Satyshur, Kelsey Eickstaedt, Nicholas V Cozzi, Timur Mavlyutov, Abdol R Hajipour, Arnold E Ruoho

2014/4

Biochemistry

American Chemical Society

Indolethylamine-N-methyltransferase (INMT) is a Class 1 transmethylation enzyme known 
for its production of N, N-dimethyltryptamine (DMT), a hallucinogen with affinity for various 
serotonergic, adrenergic, histaminergic, dopaminergic, and sigma-1 receptors. DMT is 
produced via the action of INMT on the endogenous substrates tryptamine and S-adenosyl-L-
methionine (SAM). The biological, biochemical, and selective small molecule regulation of 
INMT enzyme activity remain largely unknown. Kinetic mechanisms for inhibition of rabbit ...