Efficient and Fast Method for the Preparation of Diaryl Ketones at Room Temperature

Abdol Reza Hajipour, Raheleh Pourkaveh

2014

Synlett

EFirst

© Georg Thieme Verlag

Abstract Palladium-catalyzed cross-coupling reaction of arylboronic acids with acid 
chlorides at room temperature under phosphine-free conditions affords the corresponding 
aromatic ketones in excellent yields within short times. This synthetic method overcomes 
common disadvantages of Friedel–Crafts acylation procedures and is compatible with both 
electron-donating and electron-withdrawing substituents on the aryl ring of the acyl 
chlorides.