Pharmacokinetics of pioglitazone, a thiazolidinedione derivative, in male Naeini (Iranian fat-tailed) sheep

Sayed Mehdi Ghoreishi, H Rajaian, Majid Sheykhzade, M Alikhani, HR Rahmani, AR Hajipour, M Khorvash, HR Khodaei

2012/9/1

Journal of Applied Animal Research

40

3

208-214

Taylor & Francis Group

Pioglitazone (PGT) belongs to thiazolidinedione (TZD) family or insulin sensitizers that are 
potent ligands for peroxisome proliferator activated receptor gamma and are used in the 
treatment of type 2 diabetes mellitus. It has been shown that injection of TZD in cattle has 
some useful effects on blood parameters but there is no published study with respect to the 
feeding of TZDs in ruminants till now. Therefore, the aim of this study was to determine the 
bioavailability and several other pharmacokinetic parameters of PGT in sheep. A single ...