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Sigma-1 receptor ligands and methods of use
Inventors
Arnold E Ruoho, Abdol R Hajipour, Uyen B Chu, Dominique A Fontanilla,
Publication date
2013/1/8
Patent office
US
Patent number
8349898
Application number
12/621,246
Description
The invention provides compounds of formula I and compositions thereof. The invention
further provides methods of using the compounds and compositions. The compounds of the
invention can provide high affinity binding to sigma-1 receptors in a mammal. The
compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The
compounds and compositions of the invention can also be used to treat conditions that
involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for ...
further provides methods of using the compounds and compositions. The compounds of the
invention can provide high affinity binding to sigma-1 receptors in a mammal. The
compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The
compounds and compositions of the invention can also be used to treat conditions that
involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for ...
Journal Papers
ماه:
August
Year:
2013